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Apr 19, 2024
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2013-2014 Undergraduate and Graduate Catalog (without addenda) [ARCHIVED CATALOG]
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CBE 8373 Engineering Principles of Drug Delivery3 Credits
This course covers fundamental concepts in drug delivery from an engineering perspective. Biological organisms are viewed as highly interconnected networks where the surfaces/interfaces can be activated or altered chemically and physically/mechanically. The course focuses on the importance of intermolecular and interfacial interactions on drug-delivery carriers. Topics include drug-delivery mechanisms (passive, targeted) for metastatic cancer, in particular, and for inflammatory-type-of-diseases, in general; therapeutic modalities and mechanisms of action; engineering principles of controlled release and quantitative understanding of drug transport (diffusion, convection); effects of electrostatics, macromolecular conformation and molecular dynamics on interfacial interactions; thermodynamic principles of self-assembly; chemical and physical characteristics of delivery molecules and assemblies (polymer based, lipid based); significance of biodistributions and pharmacokinetic models; toxicity issues and immune responses.
Prerequisite(s): CBE 3313 and CBE 3323 or adviser’s approval.
Weekly Lecture Hours: 3 | Weekly Lab Hours: 0 | Weekly Recitation Hours: 0
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